In this talk, we first introduce the basic structure of tumors and consequently present some fundamental modelling aspects of tumor growth based on ODE / PDE models. We then introduce the biphasic mixture theory based mathematical model for the hydrodynamics of interstitial fluid motion and mechanical behavior of the solid phase inside a solid tumor. We introduce what is called in-vivo and in-vitro tumors considering an isolated deformable biological medium. The solid phase of the tumor is constituted by vasculature, tumor cells, and extracellular matrix, which are saturated by a physiological extracellular fluid. The mass and momentum equations for both the phases are coupled due to the interaction term. Well-posedness results will be discussed in brief. The criterion for necrosis will be shown in terms of the nutrient transport.

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Last updated: 22 Sep 2023